[关键词]
[摘要]
目的 研究泽漆Euphorbia helioscopia的化学成分。方法 利用大孔树脂,正、反相硅胶柱,MCI及Sephadex LH-20柱色谱进行分离纯化,根据波谱数据及理化性质鉴定化合物结构。结果 从泽漆全草95%乙醇提取物中分离鉴定16个化合物,包括4个萜类化合物:泽漆内酯戊(1)、对映-16β,17-二羟基-贝壳杉烷-3-酮(2)、齐墩果酸(3)、白桦脂酸(4);6个酚性化合物:苯甲酸(5)、没食子酸乙酯(6)、3,3',4,4'-四羟基联苯(7)、短叶苏木酚(8)、6-羟基-7,8-二氧亚甲基香豆素(9)、3,3'-二甲氧基鞣花酸(10);5个黄酮类化合物:芹菜素(11)、3'-甲氧基木犀草素(12)、金丝桃苷(13)、柚皮素-7-0-β-D-葡萄糖苷(14)、杨梅素-3'-O-β-D-葡萄糖苷(15)及1个甾体化合物:3β-羟基-胆甾-5-烯(16)。结论 化合物7~10、12为首次从该属植物中分离得到,化合物2~5、14~15首次从该植物分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from Euphorbia helioscopia. Methods The compounds were isolated and purified using macroporous resin, silica gel colimu, ODS, MCI gel and Sephadex LH-20, and their structures were elucidated on the basis of spectral data and physicochemical properties. Results Sixteen compounds were isolated from 95% ethyl alcohol extract from the whole arial of E. helioscopia and identified as four terpenoides:helioscopinolide E (1), ent-kaurane-3-oxo-16β-17-diol (2), oleanolic acid (3), betulinic acid (4); six phenolics:benzoic acid (5), ethyl gallate (6), 3,3',4,4'-tetrahydroxy diphenyl (7), brevifolin (8), 6-hydroxy-7,8-methylenedioxy coumarin (9), 3,3'-di-O-methylellagic acid (10); and five phenolics:apigenin (11), chrysoeriol (12), hyperin (13), naringenin-7-O-β-D-glucoside (14), cannabisci-trin (15), and 3β-hydroxy-cholesta-5-ene (16). Conclusion Compounds 7-10 and 12 are isolated from this genus for the first time. Compounds 2-5 and 14-15 are isolated from this plant for the first time.
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[基金项目]
中国药科大学大学生创新训练计划项目(201610316223)