目的 研究大鼠ig松萝酸磷脂复合物（UAPC）的药动学和组织分布特征。方法 建立大鼠血浆和各组织中松萝酸（UA）的HPLC测定方法，大鼠分别单次ig给予UA和UAPC（35.0、17.5、11.7 mg/kg，以UA计）后，测定不同时间点大鼠血浆和各组织中的UA质量浓度，采用药动学程序软件DAS 2.0计算药动学参数。结果 与UA相比，UAPC的主要药动学参数：高剂量35.0 mg/kg时C_max、AUC_0~t显著增大（P<0.05），CL显著降低（P<0.01），相对生物利用度为177.83%；中剂量17.5 mg/kg时C_max、AUC_0~t显著增大（P<0.05），CL降低明显（P<0.05），相对生物利用度为150.27%；低剂量11.7 mg/kg时C_max、AUC_0~t增大，CL降低，无显著性差异（P>0.05），相对生物利用度为109.67%。UAPC的组织分布特征：高剂量35.0 mg/kg时在肝、脾、脑组织中分布较高；中剂量17.5 mg/kg时在肺、脑组织中分布较高；低剂量11.7 mg/kg时在肝、肾组织中分布较高。结论 将UA制成UAPC后提高了UA的口服生物利用度，改变了其在大鼠某些脏器组织中的分布。

Objective To study pharmacokinetics and tissue distribution of usnic acid phospholipid complex (UAPC) in rats by oral administration. Methods HPLC was established for determination of usnic acid (UA) in the rat plasma and tissue. Rats were ig administrated UA suspension and UAPC (35.0, 17.5, and 11.7 mg/kg, with UA count). The concentrations of UA in plasma and tissue were determined by HPLC at the different time points. The pharmacokinetic parameters were calculated by the DAS 2.0 software. Results Compared with the administration of UA, the main pharmacokinetic parameters of UAPC:C_max, AUC_0-t of UAPC increased significantly (P < 0.05) and CL significantly decreased (P < 0.01) at a dose of 35 mg/kg, the relative bioavailability was 177.83%; C_max, AUC_0-t of UAPC increased (P < 0.05) and CL decreased (P < 0.05) obviously at a dose of 17.5 mg/kg, the relative bioavailability was 150.27%; While C_max and AUC_0-t increased, CL remained unchanged (P > 0.05) after ig administrations of UAPC at a dose of 11.7 mg/kg, the relative bioavailability of UAPC was 109.67%. The tissue distribution of UAPC:UAPC was distributed more in the liver, spleen and brain at a dose of 35 mg/kg; UAPC was distributed more in the lung and brain at a dose of 17.5 mg/kg; And UAPC was distributed more in the liver and kidney at a dose of 11.7 mg/kg. Conclusion Phospholipid complex improve the oral bioavailability of UA, and change the distribution in the tissue of rats.

重庆市科委基础与前沿研究计划项目（cstc2014jcyjA10037）；重庆市教委科学技术研究项目（KJ1709218）