目的 优选加味四妙颗粒（MSG）的提取工艺。方法 采用HPLC测定红景天苷、绿原酸、甘草酸铵、盐酸小檗碱、甘草苷的含量，以此5种指标成分的提取率、干膏收率及指纹图谱相似度为综合评分指标，通过正交试验考察料液比、提取时间和提取次数对提取工艺的影响，采用信息熵赋权法确定各指标的客观权重，实现对提取工艺的正交试验优选。结果 根据综合评分结果，确定该制剂最佳提取工艺为加10倍量水，煎煮2次，每次30 min。3批验证综合评分均值为88.91，RSD为0.61%。结论 优选后的工艺提取率高、稳定性和重复性好，适用于该制剂的工业化生产。

Objective To optimize the optional extraction process parameters of Modified Simiao Granule (MSG). Methods HPLC was employed to determine the content of rhodoglycoside, chlorogenic acid, ammonium glycyrrhizate, berberine hydrochloride, and glycyrrhizin, using the extraction ratio, dried cream yield, and fingerprint similarity of which as comprehensive evaluation indexes, orthogonal test was used to investigate effects of solid-liquid ratio, extraction time and times on extraction process. Information entropy method was used to determine the objective weight of each index to achieve orthogonal test optimization of extraction process. Results According to the result of comprehensive score, the optimal extraction conditions of this preparation were as follows:extracted twice with 10 times of water quantity, each for 30 min. The mean of the three batches of comprehensive evaluation was 88.91 and the RSD value was 0.61%. Conclusion The optimized technologies are stable, repeatable, feasible and suitable for the industrial production of MSG.

成都中医药大学附属医院课题（2016-D-YY-03）