[关键词]
[摘要]
树突状细胞(dendritic cells,DCs)是连接先天免疫和获得性免疫的关键。在感染和过敏反应中,DCs作为专职抗原递呈细胞引起T细胞免疫应答,并维持自身抗原免疫耐受。DCs介导的T细胞免疫应答有益于感染性疾病以及癌症等的治疗,同时DCs诱导的免疫耐受在控制自身免疫疾病、过敏或炎性疾病中发挥作用。研究表明多种天然产物能够调控DCs的表型与功能,并在免疫疗法的临床应用中被证明有效。因此,利用天然产物调控DCs免疫功能将为开发有效且低成本的细胞治疗方法提供新的思路。对近年来关于天然产物调控DCs功能的研究进行综述,总结天然产物对DCs表型变化的影响及其对免疫应答和免疫抑制的调控作用。
[Key word]
[Abstract]
Dendritic cells (DCs) are the key to connecting innate and acquired immunity. In infections and allergic reactions, DCs, as full-time antigen-presenting cells, elicit a T-cell immune response and maintain the autoantigen immune tolerance. Mediated sarcoma immune responses are beneficial for the treatment of infectious diseases as well as cancers and the like, while the immune tolerance induced by DCs plays a role in the control of autoimmune diseases, allergies or inflammatory diseases. Studies have shown that a variety of plant components can regulate the phenotype and function of DCs and they are effective in the clinical use of immunotherapy. Therefore, the use of plant components which can regulate the immune function of DC will provide new ideas for developing effective and low-cost methods of cell therapy. This review summarizes the recent studies on the function of plant components in the regulation of DCs, the effects of plant components on the dendritic phenotypes and their regulatory roles in immune response and immunosuppression.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81360354);内蒙古医科大学科技百万工程项目(YKD2016KJBW005)