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[摘要]
目的 对海南红树植物拟海桑Sonneratia paracaseolaris地上部分进行化学成分研究。方法 采用硅胶柱色谱、ODS柱、Sephadex LH-20凝胶柱、薄层色谱、高效液相色谱等方法对拟海桑化学成分进行分离纯化,通过理化性质和多种波谱数据(1H-NMR、13C-NMR)鉴定化合物的结构。结果 从拟海桑地上部分的甲醇提取物中分离得到17个化合物,分别鉴定为植醇(1)、豆甾-4-烯-3,6-二酮(2)、豆甾-4,22-二烯-3,6-二酮(3)、胆甾醇(4)、(22E)-胆甾-5,22-二烯-3β-醇(5)、香叶木素(6)、小麦黄素(7)、5,3',5'-三羟基-7,4'-二甲氧基黄酮(8)、5-羟基-7,4'-二甲氧基二氢黄酮(9)、5-羟基-7,3',4'-三甲氧基二氢黄酮(10)、香草醛(11)、对羟基苯甲醛(12)、水杨酸(13)、反式对羟基肉桂酸乙酯(14)、4-羟基-3,5-二甲氧基苯甲醛(15)、3,4,5-三甲氧基苯甲酸(16)、3,3',4'-三甲氧基鞣花酸(17)。结论 除化合物4、11、15、17外其余化合物均为首次从海桑属植物中分离得到,所有化合物均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of the methanol extract from the aerial parts of the mangrove plant Sonneratia paracaseolaris. Methods The methanol extract was isolated and purified with various chromatographic methods, including silica gel, ODS, Sephadex LH-20 columns, TLC, and HPLC. The compounds were identified by their physical chemical properties and 1H-NMR and 13C-NMR data. Results Seventeen compounds were obtained from the methanol extract of Sonneratia paracaseolaris and identified as phytol (1), stigmasta-4-ene-3,6-dione (2), stigmata-4,22-diene-3,6-dione (3), cholesterol (4), (22E)-cholesterol-5,22-diene-3β-alcohol (5), diosmetin (6), tricin (7), 5,3',5'-trihydroxy-7,4'-dimethoxyflavone (8), 5-hydroxy-7,4'-dimethoxyflavone (9), 5-hydroxyl-7,3',4'-trimethoxydihydroflavone (10), vanillin (11), p-hydroxy benzaldehyde (12), salicylic acid (13), trans-p-hydroxyl ethyl cinnamate (14), 4-hydroxy-2,6-dimethoxy-benzaldehyde (15), 3,4,5-trimethoxybenzoic acid (16), and 3,3',4-trimethoxyellagic acid (17). Conclusion All the compounds except 4, 11, 15, and 17 are obtained from genus Sonneratia. All compounds are isolated from S. paracaseolaris for the first time.
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[基金项目]
国家自然科学基金资助项目(8150130116);山东省自然科学基金项目(ZR201709220374);滨州市科技发展计划(2015ZC0304);滨州医学院科研启动基金(BY2015KYQD31)