目的 研究藏药大花龙胆Gentiana szechenyii花枝乙醇提取物的正丁醇部位的化学成分。方法 通过制备高效液相色谱法分离纯化，利用各种谱学技术鉴定化合物的结构。结果 从大花龙胆花枝乙醇提取物的正丁醇部位分离得到6个化合物，分别鉴定为大花龙胆酯苷A（1）、大花龙胆苷A（2）、异金雀花素-2"-O-吡喃葡萄糖苷（3）、异金雀花素（4）、乌奴龙胆苷D（5）和平龙胆酯苷（6）。结论 化合物1为1个新的环烯醚萜苷类化合物，命名为大花龙胆酯苷A。

Objective To investigate the chemical constituents of n-butanol fraction of the ethanol extracts from spray of Gentianae szechenyii. Methods The chemical constituents were isolated and purified by repeated preparative high-performance liquid chromatography. The structures of the isolated compounds were identified on the basis of extensive spectroscopic techniques. Results Six compounds were obtained in n-butanol fraction of the ethanol extracts from G. szechenyii and identified as gentizechenlioside A (1), szechenyin A (2), isoscoparin-2"-O-glucopyranoside (3), isoscoparin (4), gentiournosides D (5), and depressine (6). Conclusion Compound 1 is a new iridoid glycoside which named as gentizechenlioside A.

国家自然科学基金青年项目：不同化学表型藏药白花龙胆"异质同效"的药效物质基础及功能基因差异研究（81603395）；成都中医药大学科学发展基金成果转化项目：藏药龙胆花健康产品转化（CGPY1604）