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[摘要]
目的 对连翘Forsythia suspensa的化学成分进行研究。方法 通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果 从连翘的50%乙醇提取物中分离得到2个化合物,分别鉴定为(2R,3S)-3-(4-羟基-3-甲氧基苯)-3-甲氧基丙烷-1,2-二醇(1)和2-甲基己烷-1,2,3,6-四醇(2)。结论 化合物1 为新立体构型化合物,化合物2 为新化合物,分别命名为(2R,3S)-forsythiayanoside D和连翘己四醇。
[Key word]
[Abstract]
Objective To study the chemical constituents from the fruits of Forsythia suspensa. Methods Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by physiochemical properties and spectral analysis. Results Two new compounds from the 50% ethanol extract of F. suspensa were isolated and identified as (2R,3S)-3-(4-hydroxy-3-methoxyphenyl)-3-methoxypropane-1,2-diol (1) and 2-methylhexane-1,2,3,6-tetraol (2). Conclusion Compound 1 is a new epimer of a known phenylpropanoid named (2R,3S)-forsythiayanoside D, and compound 2 is a new compound named rengyquaol.
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[基金项目]
黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2017201);2015年哈尔滨商业大学博士科研启动项目(批准号15KJ21)