[关键词]
[摘要]
蓝布正为我国民间传统药物,常用于治疗头痛头晕、小儿惊风、高血压、腰腿疼痛、月经不调等疾病,然而其潜在的药理作用机制尚不明了。截至目前,蓝布正中已发现的化学成分主要有萜类(主要为单萜、倍半萜和三萜类)、鞣质类、苯丙素类等。研究显示,蓝布正具有抗凝血、抗高血压、抗炎、抗肿瘤和治疗缺血性疾病等多种药理作用。对近40年来国内外关于蓝布正的活性成分、药理作用的研究进展进行综述,为蓝布正临床合理推广应用与相关新药的研发提供参考。
[Key word]
[Abstract]
Aleppo Avens, a traditional Chinese medicine, has been commonly used for the treatment of headache and dizziness, infantile convulsion, hypertension, lumbar and leg pain, irregular menstruation, and so on. However, the underlying mechanisms of the functions remain unclear. Up to the present, terpenoids (monoterpene, sesquiterpene and three terpenoids), tannins and phenylpropyl esters were found as the main chemical composition in Aleppo Avens. Accumulating studies showed that Aleppo Avens possess the pharmacological profile of anticoagulant, antihypertensive, anti-inflammatory, anticancer, and anti-ischemia. The present paper reviewed the researches of active ingredients and pharmacological effects of Aleppo Avens in recent 40 years, and provided the pharmacological basis for the clinical application and further rational development of Aleppo Avens.
[中图分类号]
[基金项目]
缺血性心脑疾病转化医学重点实验室(三峡大学)开放基金课题(2017KXN08)