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[摘要]
目的 研究东北岩高兰Empetrum nigrum var.japonicum全草的化学成分。方法 采用硅胶柱色谱和高效液相色谱等分离手段,对东北岩高兰甲醇提取物正己烷萃取物的化学成分进行分离,并经波谱数据分析鉴定化合物的结构。结果 分离得到12个三萜类化合物,分别鉴定为岩高兰三萜-3β,21,22-三醇(1)、21,22-二羟基岩高兰三萜-3-酮(2)、21β-羟基岩高兰三萜-22(29)-烯-3-酮(3)、乙酰表木栓醇(4)、木栓酮(5)、表木栓醇(6)、木栓醇(7)、岩高兰三萜-21-烯-3-酮(8)、熊果醇(9)、24-亚甲基环阿尔廷醇(10)、β-香树脂醇(11)、熊果酸(12)。结论 化合物1、2为新化合物,命名为岩高兰三醇A和岩高兰酮B,化合物3~7、9~11为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of the whole herbs of Empetrum nigrum var. japonicum. Methods Compounds were isolated from n-hexane fraction in the methanol extract from the whole herbs of E. nigrum var. japonicum by silica gel column chromatography and HPLC. Their structures were identified by analysis on their spectral data. Results Twelve compounds were isolated and identified as nigrum-3β,21,22-triol (1), 21,22-dihydroxynigrum-3-one (2), 21β-hydroxynigrum-22 (29)-en-3-one (3), acetyl epirfriedelanol (4), friedelin (5), epirfriedelanol (6), friedelanol (7), nigrum-21-en-3-one (8), uvaol (9), 24-methylenecycoartanol (10), β-amyrin (11), and ursonic acid (12). Conclusion Compounds 1-2 are new compounds named as nigrumtriol A and nigrumone B. Compounds 3-7 and 9-11 are isolated from the plants for the first time.
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[基金项目]
内蒙古自治区自然科学基金项目(2017MS0212)