中华中医药学会中药实验药理专业委员会.变应性鼻炎动物模型制备规范(草案)[J].中草药,2018,49(1):50-57
变应性鼻炎动物模型制备规范(草案)
Specification for preparation of allergic rhinitis animal model (draft)
投稿时间:2017-10-19  
DOI:10.7501/j.issn.0253-2670.2018.01.006
中文关键词:  变应性鼻炎  动物模型  规范  草案  病症特点
英文关键词:allergic rhinitis  animal model  specification  draft  characteristics of clinical symptoms
基金项目:国家"十一五"支撑计划项目(2008BAI53B09);国家中医药管理局中医药标准化专项(2017-149-11)
作者单位
中华中医药学会中药实验药理专业委员会  
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中文摘要:
      变应性鼻炎(allergic rhinitis,AR)是机体暴露于变应原后由免疫球蛋白(IgE)介导的鼻黏膜非感染性慢性炎性疾病,其以突然发作的鼻痒、喷嚏、过量的鼻分泌物和鼻塞症状为主要临床表现,间断性、常年性或季节性发作。现变应性鼻炎动物模型为病理性模型,以西医指标为主。基于对变应性鼻炎中西医临床病症特点分析及对现有动物模型大量实验研究,形成变应性鼻炎动物模型制备规范(草案)。
英文摘要:
      Allergic rhinitis (AR) is a non infectious chronic inflammatory disease of nasal mucosa mediated by IgE after exposure to allergens. The main clinical manifestations is of sudden onset of nasal itching, sneezing, excessive nasal secretions, and nasal congestion symptoms with intermittent, perennial or seasonal attacks. The AR animal model is a pathological model based on Western medicine indexes. According to the characteristics of AR clinical symptoms of traditional Chinese medicine and Western medicine and a large number of experimental researches on existing animal models, the preparation specification (draft) of AR animal models was formed.
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