[关键词]
[摘要]
目的 研究菝葜属植物小果菝葜Smilax davidiana根茎的化学成分。方法 采用反相硅胶(RP18)、半制备HPLC色谱法等多种方法分离纯化,并对化合物进行结构鉴定。结果 从小果菝葜根茎70%乙醇提取部位分离得到20个化合物,分别鉴定为香橙素7-O-β-D-吡喃葡萄糖苷(1)、黄檀素(2)、3,5,7,4'-四羟基黄酮-7-O-β-D-吡喃葡萄糖苷(3)、山柰酚-7-O-β-D-吡喃葡萄糖苷(4)、槲皮素-7-O-β-D-吡喃葡萄糖苷(5)、槲皮素-3-O-β-L-鼠李糖(6)、4,6-二羟基-2-O-(β-D-吡喃葡萄糖苷)苯乙酮(7)、3,5-二羟基-4-O-(β-D-吡喃葡萄糖苷)苯乙酮(8)、2,4,6-三羟基苯乙酮-4-O-β-D-吡喃葡萄糖苷(9)、2,4,6-三羟基苯乙酮-2,4-二-O-β-D-吡喃葡萄糖苷(10)、表儿茶素(11)、latifolin(12)、3'-O-(E-4-酰基)-奎尼酸(13)、5-O-咖啡酰奎宁酸丁酯(14)、5,5'-二甲氧基落叶松树脂醇4'-O-β-D-吡喃葡萄糖苷(15)、1-O-二十六烷酰基甘油酯(16)、cinchonain Ib(17)、腺嘌呤核苷(18)、白藜芦醇(19)和3,4,5-三甲氧苯基-1-β-D-吡喃葡萄糖苷(20)。结论 化合物4~9、12 ~16 均为首次从菝葜属植物中分离得到,1 ~3、17、18 为首次从小果菝葜中分离得到。
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[Abstract]
Objective To study on the chemical constituents from the rhizome of Smilax davidiana. Methods The compounds were separated and purified by sephadex LH-20 column chromatography and high performance liquid chromatography. Their structures were identified by spectroscopic analysis and comparison with literatures. Results Twenty compounds were isolated and identified as aromadendrin7-O-β-D-glucopyranoside (1), dalbergin (2), 3,5,7,4'-tetrahydroxyflavanone-7-O-β-D-glucopyranoside (3), kaempferol-7-O-β-D-glucopyranoside (4), quercetin-7-O-β-D-glucopyranoside (5), quercetin-3-O-β-L-rhamnopyranoside (6), 4,6-dihydroxy-2-O-(β-D-glucopyranosyl)-acetophenone (7), 3,5-dihydroxy-4-O-(β-D-glucopyranosyl) acetophenone (8), 2,4,6-trihydroxy-acetophenone-4-O-β-D-glucopyranoside (9), 2,4,6-trihydroxylacetophenone-2,4-di-O-β-D-glucopyranoside (10), epicatechin (11), latifolin (12), 3'-O-(E-4-coumaroyl)-quinic acid (13), 5-O-caffeoylquinic acid butyl ester (14), 5,5'-dimethoxylariciresinol 4'-O-β-D-glucopyranoside (15), 1-cerotoylglycerol (16), cinchonain Ib (17), adenosine (18), resveratrol (19), and 3,4,5-trimethoxyphenyl-1-β-D-glucopyranoside (20). Conclusion Compounds 4 -9, and 12 -16 are isolated from Smilax genus for the first time, and compounds 1 -3, 17, and 18 are from S. davidiana for the first time.
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[基金项目]
国家自然科学基金资助项目(31370376,81360628,81560640);省科技计划项目(20151BBG70141)