[关键词]
[摘要]
纳米混悬凝胶剂(NS-gel)是基于纳米混悬体系的分子凝胶剂,是将纳米混悬剂或纳米混悬剂固体化所得纳米粉末与凝胶基质及其他辅料混合均匀制成的凝胶制剂,具有纳米混悬剂和凝胶剂的双重优势。综述NS-gel的制备与评价、影响其经皮给药吸收的因素,以及其在中药经皮给药中的应用进展,并对NS-gel研究存在的问题进行分析,以期为NS-gel在中药经皮给药中的深入研究与发展提供借鉴和思考。
[Key word]
[Abstract]
Nanosuspension based gel (NS-gel) is molecular gel based on nanosuspension system. NS-gel is developed by incorporating nanosuspension or nano powders obtained by solidification of nanosuspension with gel matrix and other excipients, which has dual advantages of nanosuspension and gel. This paper reviews the preparation and evaluation of NS-gel, the factors influencing the transdermal absorption of NS-gel and its application progress in transdermal drug delivery of Chinese materia medica (CMM), and analyzes the problems of NS-gel research, so as to provide reference and thinking for the further study and development of NS-gel in transdermal drug delivery of CMM.
[中图分类号]
[基金项目]
后勤科研重点项目(BKJ16J025);国家自然科学基金项目(81573697)