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[摘要]
目的 对茜草Rubia cordifolia地上部分化学成分进行研究。方法 利用硅胶、Sephadex LH-20、MCI等多种色谱材料进行分离纯化,根据波谱数据和理化性质鉴定化合物的结构。结果 共分离得到11个木脂素类成分,分别鉴定为(-)-表丁香脂素(1)、开环异落叶松脂素(2)、(-)-3,4-二香草基四氢呋喃(3)、lignans (+)-demethoxypinoresinol(4)、(+)-丁香脂素(5)、异落叶松脂素(6)、橄榄树脂素(7)、(7S,8R)-二氢脱氢双松柏醇(8)、4,5'-二甲基落叶松脂醇(9)、(+)-7R,8S-5-methoxydihydrodehydroconifery alcohol(10)、5,5'-二甲氧基-7-氧代落叶松脂醇(11)。结论 以上化合物均为首次从该植物中分离得到。
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[Abstract]
Objective To investigate the chemical constituents of the aerial part of Rubia cordifolia. Methods All compounds were isolated and purified by silica gel, Sephadex LH-20, and MCI column chromatography. Their structures were determined by physicochemical properties and spectral data. Results Eleven compounds were isolated and identified as:(−)-episyringaresinol (1), (−)-secoisolariciresinol (2), (−)-3,4-divanillyl tetrahydrofuran (3), lignans (+)-demethoxypinoresinol (4), (+)-syringaresinol (5), (+)-isolariciresinol (6), burselignan (7), (7S,8R)-dihydrodehydroconiferyl alcohol (8), 4,5'-dimethoxy-lariciresinol (9), (+)-7R,8S-5-methoxydihydrodehydroconifery alcohol (10), and 5,5'-dimethoxy-7-oxolariciresinol (11). Conclusion All compounds are isolated from this plant for the first time.
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