目的 研究云实Caesalpinia decapetala种子的化学成分。方法 采用硅胶、Sephadex LH-20等柱色谱技术对云实种子的乙醇提取物进行前处理，进而运用半制备高效液相色谱进行分离，采用NMR、MS等波谱方法进行鉴定。结果 从云实种子的氯仿部位分离得到了5个卡山烷二萜类化合物，根据NMR、MS等数据鉴定为云实二萜F1（1）、α-caesalpin（2）、caesalmin F（3）、caesalmin C（4）、caesalmin E（5）。结论 化合物1为1个新化合物，命名为云实二萜F1；化合物4、5为首次从该植物中分离得到。化合物1、4和5对人宫颈癌HeLa细胞均有一定的抑制作用，其IC₅₀分别为64.3、42.9、81.2 μmol/L。

Objective According to the folk application, the chemical constituents of the seeds of Caesalpinia decapetala were studied. Methods Silica gel and Sephadex LH-20 column chromatography techniques were used as pretreatments for ethanol extract of the seeds of C. decapetala, and then semi-preparative HPLC technique was used. Structures were identified by NMR and MS spectra. Results Five cassane-type diterpenes were isolated from the chloroform extract of C. decapetala. According to NMR and MS spectra data, the isolated compounds were identified as caesalmin F1 (1), α-caesalpin (2), caesalmin F (3), caesalmin C (4), and caesalmin E (5). Conclusion Compound 1 is a new compound, and compounds 1, 4 and 5 are isolated for the first time from C. decapetala. Compounds 1, 4 and 5 show moderate anti-tumor activity against HeLa cells with IC₅₀ values of 64.3, 42.9, and 81.2 μmol/L, respectively.

国家自然科学基金青年项目（81403088）；湖南省教育厅优秀青年项目（16B213）；湖南省重点学科建设项目（JSU0713）