[关键词]
[摘要]
随着现代中药制剂的发展,中药制剂设计面临越来越多的问题,而如何使中药制剂剂型设计有理有据成为主要问题之一,也是最难解决的问题,化学药制剂的设计是基于化学物质的生物药剂学性质,在中药整体观基础上,简述中药组分的源由,结合中药组分方面的研究成果以及化学药制剂设计的依据,提出中药组分构成的确定、组分离散度指标分析及相似性分析、权重系数法、药效贡献率系数法表征中药组分的整体性质的研究思路,为中药组分制剂的发展提供一定科学依据。
[Key word]
[Abstract]
With the development of the modern Chinese materia medica (CMM) preparation, the design of CMM preparation faces more and more problems. Chemical medicine preparation design is based on biopharmaceutical properties. However, the question that how to make CMM preparation dosage form design reasonable becomes one of the main problems and the most difficult problem to solve. Based on the wholism concept of traditional Chinese medicine, this paper summarizes the components of the source. Through the research in CMM composition for many years, combining with the design basis of chemical medicine preparations, this study put forward research thoughts that selecting representative elements of CMM component, performing component "divergence" data analysis, similarity analysis, the weight coefficient method, and the efficacy contribution coefficient method to characterize the whole property of CMM components, in order to provide scientific basis for CMM components preparation.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(H2806/81503265)