目的 研究灯盏花最细粉对慢性肾功能衰竭大鼠的保护作用。方法 雄性SD大鼠40只，随机分为对照组、模型组、灯盏花最细粉组和普通粉组。对照组常规喂养，其余3组ig腺嘌呤（250 mg/kg）制备慢性肾功能衰竭大鼠模型，持续喂养21 d。造模成功后，对照组和模型组大鼠ig等体积蒸馏水，灯盏花最细粉组和普通粉组按照3 g/kg的剂量每天ig给予相应的灯盏花粉1次，持续治疗42 d。观察各组大鼠的一般情况，测定大鼠血肌酐（Scr）、血尿素氮（BUN）；实时荧光定量PCR（qRT-PCR）法检测肾脏转化生长因子β1（TGF-β1）、纤溶酶原激活物抑制因子-1（PAI-1） mRNA的表达；ELISA法检测大鼠肾组织肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平；光镜观察大鼠肾组织形态学改变。结果 与模型组比较，灯盏花最细粉组和普通粉组大鼠的Scr、BUN水平均降低（P<0.05），肾组织TGF-β1、PAI-1 mRNA的表达水平下降（P<0.05），TNF-α和IL-1β量降低（P<0.05），病理改变也有不同程度的减轻。灯盏花最细粉组的治疗效果优于普通粉组。结论 灯盏花对慢性肾功能衰竭大鼠具有很好的保护作用，且最细粉的治疗效果优于普通粉。

Objective To observe the effects of superfine powder of Erigeron breviscapus on chronic renal failure (CRF) in rats induced by adenine. Methods SD rats were randomly divided into control group, model group, superfine powder and common powder of E. breviscapus groups, 10 rats in each group. The control group received routine feeding, while the other three groups received intragastrically (ig) with adenine (250 mg/kg) for 21 d to establish rat CRF models. Then, the rats in the control group and model group were received ig with equal volume of distilled water. Also, the rats in the superfine powder and common powder of E. breviscapus group were administered ig with E. breviscapus (3 g/kg) for 42 d. During the experiment, the general condition of each group of rats were observed and the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) were determined. Expressions of transforming growth factor-β1 (TGF-β1) and plasminogen activator inhibitor-1 (PAI-1) at mRNA level were determined by qRT-PCR. Concentrations of kidney tissue inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were determined by ELISA. Moreover, the kidney tissue was taken for histopathological observation. Results The rats in CRF model group after treatment with superfine and common powder of E. breviscapus appeared different levels of decrease of Scr, BUN, TNF-α, IL-1β, and mRNA expression of TGF-β1 and PAI-1 (P < 0.05). The pathologic changes of kidney tissue were also alleviated in different degrees. The treatment effect of superfine powder of Erigeron breviscapus was better than that of common powder group. Conclusion E. breviscapus has a good renal protective effect in rats with CRF. Furthermore, the superfine powder is more effective than the common powder in the protective effects of renal.