通过数据挖掘研究甘草在方剂中的配伍应用规律。应用计算机编程将中医方剂数据库中含有甘草的26 185首方剂信息读取为便于数据分析的形式，统计与甘草配伍较多的中药，对甘草与这些中药的配比，所治疾病科属，方剂功效及配比与科属、功效间的联系进行挖掘。通过数据挖掘发现甘草常与人参、当归、茯苓、芍药、姜、白术等药配伍应用，各药对配伍时常用比例多为1：1，多用于内科疾病，常见方剂功效包括清热、止痛、化痰止咳平喘、温里、补虚、止呕、祛风化湿等。甘草的药性及功效是其配伍应用的基础，通过配伍应用起到增效减毒的目的，为甘草功效基础研究提供依据，为其临床应用提供参考。

To study the compatibility and application rules of Glycyrrhizae Radix et Rhizoma (GRR) in prescription by data mining. Using computer programming method to transform the information of 26 185 formulas containing GRR in traditional Chinese medicine recipe database to facilitate data analysis. Firstly, the herbs frequently compatible with GRR are found. Then the proportion of GRR and another medicine, family and genus of the diseases treated are counted, the efficacy of formulas as well as their relationship. Through data mining, it is found that GRR often used with Panax ginseng, Angelica sinensis, Poria cocos, Paeonia lactiflora, Zingiber officinale, Atractylodes macrocephala, and other drugs. The most commonly used ratio is 1:1. These herb-pairs are usually used for internal medical diseases and exerting clearing heat, relieving pain, resolving phlegm and relieving cough and asthma, interior-warming, reinforcing deficiency, and checking retching effect, etc. The properties and functions of GRR are the basis of its compatibility. The compatibility of GMM can increase efficiency and reduce toxicity. This paper will provide a basis for the research of the efficacy of GMM and provide reference for its clinical application.

国家重点基础研究发展计划（“973计划”）（2011CB505300，2011CB505303）