目的 对六经头痛片进行网络药理学研究，探究其治疗偏头痛的作用机制。方法 选取六经头痛片中的18个入血及活性成分为研究对象，依据反向药效团匹配方法预测化合物的作用靶点，借助MAS 3.0生物分子功能软件及京都基因与基因组百科全书（KEGG）数据库获取相关通路并进行关联分析，最后利用Cytoscape软件构建六经头痛片"化合物-靶点-通路-疾病"的网络药理图。结果 实验表明，18个化合物可通过72个作用靶标作用于88条通路，其中36个蛋白靶点和22条通路与偏头痛相关。结论 六经头痛片可能通过干预与血管内稳态、炎症、神经中枢、免疫及激素调节等相关通路，起到疏风活络、利窍止痛的作用从而治疗偏头痛。

Objective To study the mechanisms of Liujing Toutong Tablets (LTT) in the treatment of migraine by network pharmacology. Methods Eighteen components of LTT absorbed into blood were selected as the objects, and targets of compounds were predicted according to the reverse pharmacophore matching method. The related pathways and correlation analysis were explored by the MAS 3.0 biomolecule function software and the Kyoto Encyclopedia and Genomes (KEGG) database. Finally, the network of compound-target-pathway-disease of LTT was constructed by Cytoscape software. Results Eighteen compounds interacted with 88 pathways through 72 targets, of which 36 protein targets and 22 pathways were associated with migraine. Conclusion LTT may play a role in expelling wind and dredging collaterals, promoting orifice and pain-relieving by intervening with the related pathways of inflammation, homeostasis of blood vessels, nervous centralis, immunity, and hormonal regulation.