目的 对中药复方制剂六经头痛片进行血清药物化学研究，为确定六经头痛片药效物质成分奠定基础。方法 采用HPLC-Q/TOF-MS技术，对ig给予六经头痛片后的大鼠血浆进行分析。结果 综合分析六经头痛片体外样品、给药组血浆、空白组血浆的总离子流图、提取离子流图及质谱图等信息，鉴定了含药血浆中出现的46个移行成分，包括葛根素等24个吸收原型成分及22个代谢产物。结论 血浆中检测到的吸收原型成分和代谢产物，可能是六经头痛片的真正活性成分，为明确六经头痛片药效物质基础提供了科学依据。

Objective To study the serum pharmacochemistry of Liujing Toutong Tablets (LTT). This study could be helpful to elucidate the bioactive constituents of LTT. Methods HPLC-Q/TOF-MS was used to analyze the ingredients in rats blood plasma with LTT (ig). Results By comparing the information on the total ion chromatogram, extraction chromatogram and the mass spectrogram of LTT, rat serum with drug and blank serum sample was used to confirm the constituents of LTT in vivo. As a result, a total of 46 compounds were detected in rat plasma, including 24 absorbed prototype constituents, such as puerarin, and 22 of the metabolites. Conclusion The compounds are absorbed into the blood might function as real bioactive constituents and this study can provide a scientific fundament for bioactive substances of LTT.