桃叶珊瑚苷在植物界中分布广泛，是玄参、杜仲、车前草等常用中药的有效成分之一，其药理作用也受到越来越多地关注，然而，桃叶珊瑚苷衍生物则鲜有报道。对桃叶珊瑚苷衍生物的结构类型（主要包括6-O取代型、10-O取代型、6，10-O双取代型、6'-O取代类型和其他类型）及近10年桃叶珊瑚苷及其衍生物的抗氧化、抗炎、抗菌、神经保护、抗肿瘤等药理活性进行综述。

Aucubin, one of natural active constituents, is widely distributed in Chinese materia medica, such as Scrophularia ningpoensis, Eucommia ulmoides, Plantago depressa and so on, and its pharmacolagical activities have been paid more and more attention. Nevertheless, aucubin derivatives are rarely reported. In this review, the chemical constituents of aucubin derivatives mainly included 6-O-substituent type, 10-O-substituent type, 6,10-O-disubstituent type, 6'-O-substituent type and other types, meanwhile, their pharmacological activities, such as anti-oxidant, anti-inflammatory, antibacterial, neuroprotective and antitumor activities, were summarized in the recent 10 years.

上海市优秀学术带头人计划项目（16XD1403500）；上海市"中药药效物质"E-研究院项目；上海中医药大学预算内项目（2016YSN07）