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[摘要]
目的 研究蒙药蓝刺头(驴欺口Echinops latifolius干燥花序)的化学成分。方法 采用溶剂法结合正相硅胶色谱柱、反相硅胶色谱柱以及Sephadex LH-20柱色谱,对蓝刺头的化学成分进行提取和分离纯化,利用理化鉴别及现代波谱分析技术(MS、1H-NMR、13C-NMR)鉴定化合物的结构。结果 从蒙药蓝刺头中分离鉴定了14个化合物,分别为伪蒲公英甾醇乙酸酯(1)、芹菜素(2)、胡萝卜苷(3)、13-丙基-二十五烷(4)、芹菜素-7-O-β-D-(6"-p-香豆酰基)葡萄糖苷(5)、芹菜素-7-O-葡萄糖苷(6)、咖啡酸(7)、1,5-O-双咖啡酰基奎宁酸(8)、3,5-O-双咖啡酰基奎宁酸(9)、3,4-O-双咖啡酰基奎宁酸甲酯(10)、3,5-O-双咖啡酰基奎宁酸甲酯(11)、芹菜素-7-O-β-D-(4"-p-香豆酰基)葡萄糖苷(12)、3,4-O-双咖啡酰基奎宁酸(13)、1-O-甲基-3,5-O-双咖啡酰基奎宁酸甲酯(14)。结论 化合物1、4、5、12为首次从该植物中分离得到,化合物7~11、13、14为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of the inflorescence of Echinops latifolius as a Mongolia herbal medicine. Methods The compounds were and purified by column chromatography on silica gel, ODS, and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic methods, including MS and NMR. Results Fourteen compounds were isolatied from the inflorescence of E. latifolius Tausch, and identified as ψ-taraxasteryl acetate (1), apigenin (2), daucosterol (3), 13-propyl-pentacosane (4), apigenin 7-O-(4"-O-p-coumaroyl)-β-glucoside (5), apigenin-7-O-glucoside (6), caffeic acid (7), 1,5-O-dicaffeoylquinic acid (8), 3,5-O-dicaffeoyl quinic acid (9), methyl 3,4-O-dicaffeoyl quinic acid (10), methyl 3,5-O-dicaffeoyl quinic acid (11), apigenin 7-O-β-D-(4"-p-coumaroyl) glucoside (12), 3,4-O-dicaffeoyl quinic acid (13), and methyl-1-O-methyl 3,5-O-dicaffeoyl quinic acid (14). Conclusion Compounds 1, 4, 5, and 12 are isolated from this plant for the first time. Compound 7-11, 13, and 14 are isolated from the genus Echinops for the first time.
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[基金项目]
内蒙古自治区高等学校科学研究项目(NJZY16104);内蒙古自然科学基金项目(2017MS08122);内蒙古自治区"草原英才"工程项目(NMGCYYC2013);国家自然基金资助项目(31000160);新疆维吾尔自治区青年科技创新人才培养工程-杰出青年科技人才培养项目(2013711020)