[关键词]
[摘要]
目的 对拳距瓜叶乌头Aconitum hemsleyanum var. circinatum的块根进行化学成分研究。方法 采用柱色谱方法进行分离纯化,结合波谱数据(1H-NMR、13C-NMR、MS)进行结构鉴定。结果 从拳距瓜叶乌头块根总生物碱中共分离得到17个二萜生物碱,分别鉴定为黄草乌碱丁(1)、8-甲氧基黄草乌碱丁(2)、贡乌生(3)、塔拉地萨敏(4)、查斯曼宁(5)、8-甲氧基塔拉胺(6)、14-乙酰塔拉胺(7)、8-去乙酰滇乌碱(8)、crassicautine(9),crassicaudine(10)、粗茎乌头碱甲(11)、黄草乌碱丙(12)、黄草乌碱甲(13)、滇乌碱(14)、transconitine B(15)、工布乌碱(16)、大渡乌碱(17)。结论 化合物2、3、6、7、9、12~16为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in the roots of Aconitum hemsleyanum var. circinatum. Methods The constituents were isolated and purified by silica gel chromatography from the roots of Aconitum hemsleyanum var. circinatum, and the structures were identified by spectral analysis (1H-NMR, 13C-NMR, and MS). Results Seventeen compounds were isolated from Aconitum hemsleyanum var. circinatum and characterized as sachaconitine (1), 8-O-methylsachaconitine (2), liljestrandisine (3), talatisamine (4), chasmannine (5), 8-O-methyltalatisamine (6), 14-O-acetyltalatisamine (7), 8-deacetyl-yunaconitine (8), crassicautine (9), crassicaudine (10), crassicauline A (11), vilmorianine C (12), vilmorianine A (13), yunaconitine (14), transconitine B (15), kongboendine (16), and franchetine (17). Conclusion Seventeen compounds are isolated from Aconitum hemsleyanum var. circinatu. Compounds 2-3, 6-7, 9, and 12-16 are isolated from Aconitum hemsleyanum var. circinatum for the first time.
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[基金项目]
国家自然科学基金资助项目(21362045);云南省科技惠民专项(2016RA046)