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[摘要]
目的 对云南松Pinus yunnanensis的化学成分进行研究。方法 采用甲醇冷浸提取,再依次用石油醚、醋酸乙酯萃取,对石油醚和醋酸乙酯萃取部分采用各种柱色谱进行分离纯化,通过波谱数据分析(MS、1H-NMR、13C-NMR)进行结构鉴定。结果 从云南松枝条甲醇提取物的石油醚和醋酸乙酯萃取部分分离鉴定了14个化合物,分别为(7R,8R)-7,8-dihydro-3'-hydroxyl-7-(4-hydroxyl-3-methoxyphenyl)-8-hydroxymethyl-1'-benzofuranpropanol-4-O-(3-O-methyl-α-L-rhamnopyranoside)(1)、赤松素(2)、4-豆甾烯-3-酮(3)、山柰酚(4)、异海松醇(5)、槲皮素(6)、5,7-二羟基-双氢槲皮素(7)、双氢槲皮素(8)、3-羟基-5-甲氧基均二苯代乙烯(9)、百里醌-5-O-β-D-吡喃葡萄糖苷(10)、淫羊藿次苷E4(11)、3,4-二甲氧基苯基-1-O-β-D-葡萄糖苷(12)、黑五味子苷(13)、β-谷甾醇(14)。结论 化合物1、3~7、10~13均为首次从云南松植物中分离得到。
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[Abstract]
Objective To study the chemical constituents of Pinus yunnanensis. Methods The whole plant of air-dried P. yunnanensis was extracted with methnol. The methnol extract was suspended in H2O and extracted with petroleum, ethyl acetate, and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the petroleum and ethyl acetate fractions, and identified based on spectral analyses (MS, 1D-and 2D-NMR, IR, UV). Results Fourteen compounds were isolated from P. yunnanensis and characterized as (7R,8R)-7,8-dihydro-3'-hydroxyl-7-(4-hydroxyl-3-methoxyphenyl)-8-hydroxymethyl-1'-benzofuranpropanol-4-O-(3-O-methyl-α-L-rhamnopyranoside) (1), pinosylvine (2), stigmast-4-en-3-one (3), kaempferol (4), isopimarinol (5), quercetin (6), pinocembrin (7), taxifilin (8), 3-hydroxyl-5-methoxy-stilbene (9), 5-O-β-D-glucopyranosyl-thymoquinol (10), icariside E4 (11), 3,4-dimethoxyphenyl-1-O-β-D-glucopyranoside (12), schizandriside (13), and β-stitosterol (14). Conclusion Compounds 1, 3-7, and 10-13 are obtained from Pinus yunnanensis Lamb. for the first time.
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