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[摘要]
目的 探讨甜梦口服液在慢性阻塞性肺疾病(COPD)伴失眠治疗中的临床疗效。方法 将本院2013年2月-2015年2月收治的COPD合并失眠患者86例随机分为对照组和试验组,每组各43例。对照组采用常规治疗,试验组在对照组常规治疗基础上加服甜梦口服液治疗。治疗4周后,对比两组的临床疗效、生活质量,匹兹堡睡眠指数(PSQI)、睡眠效率、睡眠潜伏期、睡眠总时间、觉醒次数、觉醒总时间、肺功能。结果 治疗后,对照组和试验组的总有效率分别为79.07%和93.02%,两组比较差异显著(P<0.01)。治疗后,两组患者PSQI总分、睡眠潜伏期、觉醒次数、觉醒总时间、呼吸症状、活动受限均显著降低,睡眠效率、睡眠总时间、第1秒用力呼气容量(FEV1)、和FEV1/用力肺活量(FVC)均升高,同组治疗前后比较差异显著(P<0.05);且试验组这些指标的改善程度优于对照组,差异显著(P<0.05)。结论 甜梦口服液可改善COPD伴失眠患者的睡眠质量,降低PSQI评分,具有一定的临床应用价值。
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[Abstract]
Objective To observe the clinical effect of Tianmeng Oral Liquid in the treatment of chronic obstructive pulmonary disease and insomnia. Methods Patients (86 cases) with chronic obstructive pulmonary disease and insomnia from February 2013 to February 2015 were randomly divided into control group (43 cases) and experimental group (43 cases). The patients in the control group were administered with conventional therapy. The patients in the treatment group were treated with Tianmeng Oral Liquid on the basis of the control group. Each group was treated for 4 weeks. After treatment, the clinical efficacies and the quality of life were evaluated, and the changes of PSQI scores, total sleep time, sleep efficiency, sleep latency, awakening times, awakening total time, and lung function in two groups were compared. Results After treatment, the clinical efficacies were 79.07% and 93.02% in the control groups and experimental group, respectively, and there were differences between two groups (P<0.01). After treatment, PSQI scores, awakening times, awakening total time, and respiratory symptoms were significantly reduced, and total sleep time, sleep efficiency, FEV1, and FEV1/FVC were significantly increased, and the difference was significant statistically (P<0.05). And observational indexes in the experimental group were significantly better than those in the control group (P<0.05). Conclusion Tianmeng Oral Liquid can improve the sleep quality of patients with the chronic obstructive pulmonary disease and insomnia, also can reduce PSQI scores, which has a certain clinical value.
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