[关键词]
[摘要]
目的 对大籽蒿Artemisia sieversiana全草化学成分进行研究。方法 采用硅胶柱色谱和高效液相色谱等分离方法,对大籽蒿乙醇浸提液醋酸乙酯萃取物化学成分进行分离纯化,依据理化性质及波谱数据分析鉴定结构。结果 从大籽蒿醋酸乙酯萃取物中分离得到17个化合物,分别鉴定为鹅掌楸树脂醇B二甲醚(1)、(3R,6R,7E)-3-hydroxy-4,7-megastigmadien-9-one(2)、洋艾素(3)、异苦艾素(4)、安洋艾素(5)、badounoid B(6)、gnapholide(7)、洋艾内酯B(8)、11,10',11'-表洋艾素(9)、龙脑葡萄糖苷(10)、10',11'-表洋艾素(11)、2-甲基-2,3,4-三羟基-1,4-丁内酯(12)、3(Z)-己烯醇葡萄糖苷(13)、右旋肌醇甲醚(14)、黑麦草素(15)、desacetylmatricarin(16)、洋艾内酯A(17)。结论 化合物2、4~8、10、12~17为首次从大籽蒿中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Artemisia sieversiana. Methods The chemical constituents were separated and purified by column chromatography and HPLC. Their structures were determined on the basis of spectroscopic analyses. Results Seventeen compounds were isolated from A. sieversiana and the structures were identified as yangambin (1), (3R,6R, 7E)-3-hydroxy-4,7-megastigmadien-9-one (2), absinthin (3), anabsin (4), anabsinthin (5), badounoid B (6), gnapholide (7), artabsinolide B (8), 11,10',11'-epiabsinthin (9), l-borneol-β-D-glucopyranoside (10), 10',11'-epiabsinthin (11), 2-methyl-2,3,4-trihydroxybutanoic acid-1,4-lactone (12), 3(Z)-hexenyl-β-glucopyranoside (13), pinitol (14), epiloliolide (15), desacetylmatricarin (16), and artabsinolide A (17), respectively. Conclusion Compounds 2, 4-8, 10, and 12-17 are isolated from this plant for the first time.
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[基金项目]
黑龙江省自然科学基金项目(B201205)