[关键词]
[摘要]
目的 对荷花玉兰Magnolia grandiflora叶的化学成分进行研究。方法 采用硅胶、Sephadex LH-20等柱色谱方法进行化合物的分离和纯化,并根据谱学数据鉴定化合物的结构。结果 从荷花玉兰叶的70%丙酮水提取物中分离得到8个倍半萜,分别鉴定为12,13-二乙酰氧基-桉烷-4α,6α,11-三醇(1)、12,13-二乙酰氧基-5αH-愈创木烷-1(10)-烯-4α,6α,11-三醇(2)、11,13-去氢台湾含笑内酯(3)、台湾含笑内酯(4)、α-山道年(5)、1β-羟基-11βH-桉烷-3-烯-12,6α-内酯(6)、β-网翼藻萜醇(7)、12α-甲氧基-吉玛烷-1(10),4,11(13)-三烯-12,6α-缩醛(8)。结论 化合物1和2为新化合物,并命名为荷花玉兰醇A和B,化合物4~8为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the leaves of Magnolia grandiflora. Methods The chemical constituents were isolated and purified by various column chromatographic techniques, including silica gel and Sephadex LH-20, and the structures were identified by spectroscopic analyses. Results Eight sesquiterpenoids were isolated from 70% aq. acetone extract of M. grandiflora and the structures were identified as 12,13-diacetoxy-eudesma-4α,6α,11-triol (1), 12,13-diacetoxy-5αH-guaia-1 (10)-en-4α,6α,11-triol (2), 11,13-dehydrocompressanolide (3), compressanolide (4), α-santonin (5), 1β-hydroxyl-11βH-eudesma-3-en-12,6α-olide (6), β-dictyopterol (7), and 12α-methoxy-germacran-1(10), 4,11(13)-trien-12,6α-acetal (8). Conclusion Compounds 1 and 2 are new compounds named as magnogranol A and B, and compounds 4-8 are isolated from this plant for the first time.
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[基金项目]
国家自然科学基金地区项目(21662023);云南省教育厅科学研究基金指导性项目(2017zDX156);广西植物功能物质研究与利用重点实验室开放基金项目(FPRU2016-3)