中西药联合应用是临床治疗疾病的有效手段。中药作用持久温和，具有多成分、多靶点、多途径、整合调节的特点；化学药起效迅速，具有靶点明确、途径单一的特点，二者联合应用可优势互补、协同增效、降低毒副作用。P-糖蛋白是一种能量依赖型的跨膜转运蛋白，其介导的外排效应是药物传输的重要靶点。对P-糖蛋白的诱导或抑制作用是中西药联合应用时产生相互作用的重要因素。从P-糖蛋白水平对中药与化学药之间的相互作用进行了简要综述，以揭示P-糖蛋白在中西药联用中的作用，为临床中西药联用合理用药提供参考。

Chinese materia medica (CMM) in combination with chemical drug is an effective treatment for diseases. CMM sustain moderate effect, including multiple components, multiple targets, multiple pathways and integrated regulation characteristics; While the effect of chemical drug is rapid and shows definite target and single way, the combination of the two can be complementary advantages, synergistic effects and reduce toxicity. P-glycoprotein (P-gp) is a kind of energy dependent transmembrane transport protein; Its mediated efflux effect is one of important targets for drug delivery. The induction or inhibition of P-gp plays a significant factor in the interaction generated when CMM and chemical drug combined application. In this paper, interaction of CMM combined with chemical drug in P-gp level was briefly reviewed, in order to reveal the role of P-gp in joint use Chinese and Western medicine, and to provide reference for the rational use of drugs to integration of Chinese and Western medicine in clinic.

国家自然科学基金面上项目（81573825）；教育部“创新团队发展计划”项目（IRT_14R41）