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[摘要]
目的 研究金线莲Anoectochilus roxburghii的化学成分。方法 利用正相硅胶、D101大孔吸附树脂、聚酰胺树脂、ODS C18、重结晶及制备高效液相色谱进行分离纯化,根据波谱数据及理化性质进行结构鉴定。结果 从金线莲全草中分离得到19个化合物,分别鉴定为(22E,24ξ)-24-异丙烯基-22-脱氢胆甾醇(1)、anoectosterol(2)、豆甾醇(3)、β-谷甾醇(4)、赫尔西酚(5)、moscatin(6)、5,3'-二羟基-3,7,4'-三甲氧基黄酮(7)、亚油酸(8)、8,9-环氧-1,11,14-三烯(9)、香草乙酮(10)、对羟基苯甲醛(11)、对羟基苯乙酮(12)、5-羟基-3',4',7–三甲氧基黄酮醇-3-O-β-D-芸香糖苷(13)、异鼠李素-3-O-刺槐双糖苷(14)、β-腺苷(15)、异鼠李素-3-O-β-龙胆双糖苷(16)、loroglossin(17)、corchoinoside C(18)、对羟基苯甲醇(19)。结论 化合物1、16、19为首次从兰科植物中得到,化合物5~7、10、12为首次从开唇兰属植物中得到,化合物9、15、18为首次从该植物中得到。
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[Abstract]
Objective To study the chemical constituents of Anoectochilus roxburghii. Methods The chemical constituents of A. roxburghii were separated and purified by silica gel column chromatography, recrystallization, macroreticular resin, polyamide resin, ODS C18, and HPLC. Compound structures were identified by the spectral data and the physical and chemical properties. Results From this plant, nineteen compounds were obtained, such as (22E,24ξ)-24-isopropenyl-22-dehydrocholesterol (1), anoectosterol (2), stigmasterol (3), β-sitosterol (4), hircinol (5), moscatin (6), 5,3'-dyhydroxy-3,7,4'-trimethoxyflavone (7), linoleic acid (8), 8,9-epoxyheptadeca-1,11,14-triene (9), acetovanillone (10), parahydroxybenzaldehyde (11), parahydroxyacetophenone (12), 5-hydroxy-3',4',7-trimethoxyflavonol-3-O-β-D-rutinoside (13), isorhamnetin-3-O-robinobioside (14), β-adenosine (15), isorhamnetin-3-O-β-gentiobioside (16), loroglossin (17), corchoinoside C (18), and parahydroxybenzylalcohol (19). Conclusion Compounds 1, 16, and 19 are isolated from Orchidaceae for the first time; Compounds 5, 6, 7, 10, and 12 are isolated from Anoectochilus Bl. for the first time; Compounds 9, 15, and 18 are isolated from this plant for the first time.
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