[关键词]
[摘要]
目的 对云南含笑Michelia yunnanensis果实的化学成分进行研究。方法 采用硅胶、Sephadex LH-20等多种色谱技术进行分离纯化,根据波谱数据鉴定化合物的结构。结果 从云南含笑果实甲醇提取物中分离得到12个化合物,分别鉴定为13-甲氧基-11β,13-二氢木香烃内酯(1)、毛叶含笑内酯(2)、北美鹅掌楸内酯(3)、鹅掌楸内酯(4)、木香烃内酯(5)、小白菊内酯(6)、11β,13-二氢小白菊内酯(7)、4α,5β-环氧-13-甲氧基-11βH-吉玛烷-1(10)-烯-12,6α-内酯(8)、长莎草醇C(9)、香橙烷-4β,10α-二醇(10)、9-氧代橙花椒醇(11)、11,13-去氢台湾含笑内酯(12)。结论 化合物1为新天然产物,并且首次全面报道化合物1和2的1H-NMR、13C-NMR数据。除化合物6,其余化合物均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from fruits of Michelia yunnanensis. Methods The chemical constituents were isolated and purified by column chromatographies on silica gel and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic data. Results Twelve compounds were isolated from methanol extract of the fruits of M. yunnanensis and the structures were identified as 13-methoxy-11β,13-dihydrocostunolide (1), lanuginolide (2), tulipinolide (3), lipiferolide (4), costunolide (5), parthenolide (6), 11β,13-dihydroparthenolide (7), 4α,5β-epoxy-13-methoxy-11βH-germacra-1 (10)-en-12,6α-olide (8), cyperusol C (9), aromadendra-4β,10α-diol (10), 9-oxonerolidol (11), and 11,13-dehydrocompressanolide (12). Conclusion Compound 1 is isolated as a new natural product. 1H-NMR and 13C-NMR data of compounds 1 and 2 are reported for the first time. Except compound 6, other compounds are isolated from this plant for the first time.
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[基金项目]
云南省天然药物药理重点实验室开放研究基金资助项目(2015G004)