中药炮制是我国独有的具有自主知识产权的一项传统制药技术，中药炮制研究的内容包括历史沿革、炮制工艺、质量标准和炮制机制研究，而阐明中药炮制过程中化学成分变化是中药炮制机制研究的核心内容。种子类中药素有“逢子必炒”之说，其理论基础得到了国内外很多研究机构的证实，对临床常用种子类中药炮制过程化学成分变化机制进行概述，总结种子类中药炒制过程化学成分变化的共性规律，发现种子类中药炒制过程中，化学成分发生了复杂的变化，既有量变也有质变，且成分变化有一定的共性规律，即一般发生分解反应，达到炒制增效、减毒的目的。“逢子必炒”具有一定的科学内涵，应在中医药理论指导下进一步研究阐明，进而指导临床合理应用。

Chinese materia medica (CMM) processing is a traditional Chinese pharmaceutical technology with independent intellectual property rights in China, which includes historical evolution, processing technology, quality standards and processing mechanism. Clarification of the chemical constituents changes in seed Chinese materia medica (SCMM) is the core purpose of mechanism research of CMM processing. It is well known that "SCMM be stir-heated before using", which has been confirmed by many research institutions at home and abroad. This article gives a brief introduction to the chemical mechanism during SCMM processing and concludes their similarities. It has been found that the chemical constituents in SCMM have experienced complex changes both in quantitative and qualitative during processing. The main chemical reactions occurred in the SCMM processing are decomposition reaction so as to increase therapeutic effect or reduce toxicity and so on. The theory has a certain scientific connotation and it should be clarified under the guidance of the theory of traditional Chinese medicine for rational clinical use.

国家自然科学基金面上项目（81573603）；国家自然科学基金青年基金项目（81603297）；国家中医药管理局公益性行业专项（201507002-2）；江苏省普通高校研究生科研创新计划项目（KYZZ16_0413）；江苏省临床药学科研课题“南京药学会-常州四药医院药学科研基金”项目（2015YX005）