[关键词]
[摘要]
目的 研究青龙衣的化学成分。方法 采用溶剂萃取、硅胶柱色谱、高效液相色谱等方法进行分离纯化,通过核磁共振波谱、质谱等谱学数据分析鉴定结构。结果 从青龙衣75%乙醇提取物中分离得到15个化合物,分别鉴定为表二氢菜豆酸(1)、4-丁氧基-5,8-二羟基-3,4-二氢-萘酮(2)、4-乙氧基-5,8-二羟基-3,4-二氢-萘酮(3)、茸毛香杨梅苷元(4)、多节孢酮(5)、4S-甲氧基-5,8-二羟基-二氢-萘酮(6)、4-甲氧基-5-羟基-α-四氢-萘酮(7)、胡桃种萘醌(8)、4,5,8-三羟基-1,2,3,4-四氢-萘-1-酮(9)、苹果酸-1-单乙酯(10)、苹果酸-1-单丁酯(11)、丁二酸(12)、葡萄糖乙苷(13)、1α,2α,4β-三羟基-1,2,3,4-四氢萘(14)、L-2-O-甲基-手性肌醇(15)。结论 化合物5、10~14为首次从该属植物中分离得到,化合物1、4、15为首次从青龙衣中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in green walnut husks of Juglans regia. Methods The chemical constituents were separated and purified by silica gel column chromatography and HPLC. Their structures were determined on the basis of spectroscopic analyses. Results Fifteen compounds were isolated and the structures were identified as epi-dihydrophaseic acid (1), 4-butoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1-one (2), 4-ethoxy-5,8-dihydroxy-3,4-dihydronaphthalen-1-one (3), myricatomento-genin (4), nodulisporone (5), 5,8-dihydroxy-4S-methoxy-β-tethalone (6), 5-hydroxy-4-methoxy-α-naphthalen-1-one (7), isosclerone (8), 4,5,8-trihydroxy-1,2,3,4-tetrahydronaphthalene-1-one (9), 1-ethyl malate (10), 1-buthyl malate (11), succinic acid (12), ethyl-O-β-D-glucopyranoside (13), 1α,2α,4β-trihydroxy-1,2,3,4-tetrahydronaphthalene (14), and L-2-O-methyl-chiroinosicol (15). Conclusion Compounds 5 and 10-14 are isolated from the green walnut husks of J. regia for the first time, and compounds 1, 4, and 15 are isolated from this plant for the first time.
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[基金项目]
黑龙江省自然科学基金面上项目(B201209);黑龙江省教育厅青年学术骨干项目(1253G064);齐齐哈尔大学研究生创新科研项目(YJSCX2015-ZD12)