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[摘要]
目的 研究海南狗牙花Ervatamia hainanensis枝叶的化学成分。方法 采用硅胶、ODS、Sephadex LH-20及制备型HPLC等柱色谱方法进行分离纯化,根据理化性质及波谱学数据鉴定化合物结构。结果 从海南狗牙花枝叶的95%乙醇提取物中分离得到了4个木脂素类成分,分别鉴定为threo-7-O-ethylguaiacylglycerol-8-O-4'-(coniferyl alcohol) ether(1)、threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether(2)、erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether(3)、去氢二松柏醇(4)。结论 化合物1为1个新的8-O-4'-木脂素类成分,命名为海南狗牙花脂素A(1);化合物2~4为首次从狗牙花属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods The chemical constituents were isolated by silica gel, ODS, Sephadex LH-20 column chromatographies, and preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral analysis. Results Four lignans were isolated and identified as threo-7-O-ethylguaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (3), and dehydrodiconiferyl alcohol (4). Conclusion Compound 1 is a new 8-O-4'-neolignan and named as hainanervaligan A (1), and compounds 2-4 are obtained from the plants of Ervatamia (A. DC.) Stapf for the first time.
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[基金项目]
广东省自然科学基金项目(2016A030310017);广东省高等职业教育品牌专业建设项目(16061)