[关键词]
[摘要]
炎症性肠病(IBD)是一种常见胃肠道疾病,其发病原因与发病机制不明。通常认为IBD是由环境因素、遗传因素、免疫因素引起的,其相关因素包括免疫系统、氧化应激、胃肠道内微生物菌群和核转录因子-κB(NF-κB)、NO、环氧合酶-2(COX-2)、白三烯B4(LB4)等相关因子。传统维吾尔药中有许多对IBD有效的植物,如龙葵、没食子、石榴等,它们对IBD的作用机制可能涉及以上因素的一种或几种的结合。现就IBD发病因素在IBD中的作用及各种维吾尔药用植物对IBD的作用机制的研究进展进行综述。
[Key word]
[Abstract]
Inflammatory bowel disease (IBD) is a common gastrointestinal disease in which the etiology and pathogenesis are still unclear. Generally speaking, it is caused by environment, inheritance, and immune. The related factors include immune system, oxidative stress, microflora in gastrointestinal tract, NF-κB, NO, COX-2, LB4, and the correlation factors. There are many plants that are effective to inflammatory bowel disease in traditional Uygur medicine, such as Solanum nigrum, Quercus infectoria, and Punica granatum. For some of these plants, only one or two mechanisms of action have been found. Besides, some constituents of them are effective to anti-inflammatory bowel disease. This article reviewed the role of factors in IBD and the mechanism of anti-inflammatory bowel disease of traditional Uygur medicine.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81560699);广东省省级科技计划项目(2014A020209026)