[关键词]
[摘要]
目的 研究南五味子Kadsura longipedunculata根的化学成分。方法 采用正相硅胶、C18反相硅胶和葡聚糖凝胶等多种分离方法进行分离纯化,通过NMR、MS等波谱方法鉴定化合物结构。结果 从南五味子根具有抗炎活性的部位中分离得到了15个化合物,10个木脂素类化合物和5个三萜类化合物,分别鉴定为 (2S,3S)-4,4-二-(3,4-二甲氧基苯基)-2,3-二甲基-1-丁醇(1)、(2S,3S)-4,4-二-(4-羟基-3-甲氧基苯基)-2,3-二甲基-1-丁醇(2)、窄叶南五味子素K(3)、苯甲酰氧代南五味子醇(4)、丙酰氧基氧代南五味子醇(5)、冷饭团素C(6)、异形南五味子素E(7)、台湾五味子木脂素C(8)、异形南五味子素J(9)、菲律宾南五味子素J(10)、合蕊五味子二内酯J(11)、黑老虎内酯C(12)、菲律宾南五味子内酯B(13)、五味子二内酯D(14)、五味子二内酯H(15)。结论 化合物1~15均为首次从该植物中分离得到,其中化合物1、2、11、14为首次从该属植物中分离得到,化合物1和2为新的天然产物。
[Key word]
[Abstract]
Objective To study the chemical constituents from the roots of Kadsura longipedunculata. Methods The constituents were isolated and purified by various chromatographic methods, and the structures were identified on the basis of spectroscopic analysis. Results Fifteen compounds including 10 lignans and five triterpenoids were isolated from the roots of K. longipedunculata and the structures were identified as (2S,3S)-4,4-bis (3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol (1), (2S,3S)-4,4-bis (4-hydroxy-3-methoxyphenyl)-2,3-dimethyl-1-butanol (2), kadangustin K (3), benzoyloxokadsuranol (4), propoxyloxokadsuranol (5), kadsutherin C (6), heteroclitin E (7), schiarisanrin C (8), heteroclitin J (9), kadsuphilin J (10), propindilactone J (11), kadcoccilactone C (12), kadsuphilactone B (13), wuweizidilactone D (14), and wuweizidilactone H (15). Conclusion All compounds are isolated from K. longipedunculata for the first time, and compounds 1, 2, 11, and 14 are isolated from the genus Kadsura Kaempf. ex Juss. for the first time, compounds 1 and 2 are new natural products.
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[基金项目]
中国医学科学院医学与健康科技创新工程-天然产物系统创新与应用研究(CAMS-I2M-1-010)