[关键词]
[摘要]
目的 研究马钱科胡蔓藤属植物钩吻Gelsemium elegans的化学成分。方法 采用硅胶、Sephadex LH-20、HPLC等色谱方法进行分离纯化,通过理化性质及核磁共振谱学数据对分得的化合物进行结构鉴定。结果 从钩吻的95%乙醇提取物中分离得到15个化合物,分别鉴定为钩吻素子(1)、钩吻素甲(2)、钩吻绿碱(3)、钩吻素己(4)、花椒毒素(5)、香柑内酯(6)、异茴芹内酯(7)、欧前胡素(8)、蛇床子素(9)、对羟基苯甲酸(10)、香草酸(11)、β-谷甾醇(12)、β-胡萝卜苷(13)、钩吻内酰胺(14)、16-表伏康树卡平碱(15)。结论 化合物5~9为首次从该种植物中分离得到。
[Key word]
[Abstract]
Objective The chemical constituents were isolated and identified in order to find the bioactive natural products from Gelsemium elegans. Methods Silica gel, sephadex LH-20 and HPLC column chromatographic techniques were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation. Results Fifteen compounds were separated from G. elegans, identified by physicochemical properties, spectral analysis and other means. They are koumine (1), gelsemine (2), gelsevirine (3), gelsemicine (4), xanthotoxin (5), bergapten (6), isopimpinellin (7), imperatorin (8), osthol (9), p-hydroxybenzoic acid (10), vanilla acid (11), β-sitosterol (12), β-daucosterol (13), gelsemamide (14), and 16-epivoacarpine (15). Conclusion Compounds 5—9 are first isolated from the plants in genus Gelsemium Juss.
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[基金项目]
国家自然科学基金资助项目(81274182,81573687)