目的 比较盐酸小檗碱（BBH）及其磷脂固体分散体（BBH-PSD）的肠吸收特点，探讨磷脂固体分散体技术提高小檗碱生物利用度的作用机制。方法 采用大鼠单向灌流模型，HPLC法测定在体灌流液中小檗碱的质量浓度变化，分别考察不同部位、不同灌流体积流量、不同质量浓度对BBH和BBH-PSD肠吸收特性的影响，以吸收速率常数（K_a）和表观吸收系数（P_app）为指标。结果 BBH和BBH-PSD在空肠吸收最快，BBH-PSD在空肠的K_a和P_app显著高于BBH（P<0.05）；BBH-PSD在体积流量为0.2、0.4、0.8 mL/min下的K_a和P_app均显著高于BBH（P<0.05）；质量浓度的增加对BBH肠吸收的影响不显著（P>0.05），而随着BBH-PSD质量浓度的增加可显著增加BBH的肠吸收（P<0.05）。结论 磷脂固体分散体技术可促进小檗碱在各个肠段的吸收，尤其是空肠，其促进吸收机制与提高小檗碱渗透性、增强单纯扩散有关。

Objective To compare intestinal absorption features of berberine hydrochloride phospholipid solid dispersions (BBH-PSD) by rat single-pass perfusion model, and to explore the mechanism of berberine bioavailability increasing mechanism by phospholipid solid dispersion technology. Methods The single-pass perfusion model was established in rats, the concentration of berberine in intestinal perfusion was determined by HPLC, and phospholipid solid dispersion technology promoting intestinal absorption of berberine was investigated. Results Compared with berberine, BBH-PSD could promote much more absorption of berberine in various intestinal segments, especially in jejunum, and the mechanism was related to improving permeability and strengthen simple diffusion of berberine. The K_a and P_app values of BBH and BBH-PSD in jejunum were obviously higher than BBH (P< 0.05); When the volumetic flow rate of BBH-PSD was 0.2, 0.4, and 0.8 mL/min, K_a and P_app were both higher than BBH (P< 0.05); The increasing mass concentration was not obvious to intestinal absorption of BBH, while the increasing mass concentration of BBH-PSD obviously increased the intestinal absorption of BBH (P< 0.05). Conclusion Intestinal absorption characteristics of berberine phospholipid solid dispersion is beneficial to improve berberine oral bioavailability, and it can provide a scientific basis for the development of new dosage forms of berberine hydrochloride.