[关键词]
[摘要]
目的 对党参Codonopsis pilosula的水提物进行化学成分研究。方法 综合采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20和半制备液相等技术进行分离纯化,采用各种波谱技术确定化合物的结构。结果 在党参水提物的50%乙醇洗脱部位得到7个化合物,分别鉴定为(-)-(8R,9R,2E,6E,10E)-tetradeca-2,6,10-triene-4-yne-8,14-diol-9-β-D-glucopyranoside(1)、苯基-β-D-葡萄糖苷(2)、(E)-异松柏苷(3)、松柏苷(4)、丁香苷(5)、芹菜素(6)、腺苷(7)。结论 化合物1为新党参炔醇苷类化合物,命名为党参炔苷A;化合物2和3为首次从党参中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Codonopsis pilosula. Methods The chemical constituents were isolated and purified by AB-8 macroporous adsorption resin, silica gel, and Sephadex LH-20 column chromatography. The structures of the isolated compounds were identified on the basis of spectroscopic methods including 1H-NMR, 13C-NMR, CD, and MS spectra. Results Seven compounds were identified as (-)-(8R,9R,2E,6E,10E)-tetradeca-2,6,10-triene-4-yne-8,14-diol-9-β-D-glucopyranoside (1), phenyl-β-D-glucoside (2), (E)-isoconiferin (3), coniferin (4), syringin (5), apigenin (6), and adenosine (7). Conclusion Compound 1 is a new compound, named lobetyolin A, and compounds 2 and 3 are all isolated from this plant for the first time.
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[基金项目]
河北省自然科学基金项目(H2015209094,H2014209214)