目的 以维生素E聚乙二醇琥珀酸酯（VE-TPGS）和聚乙二醇硬脂酸酯15（Solutol HS 15，SHS15）为载体制备姜黄素胶束，并研究该胶束对姜黄素溶解度和口服生物利用度的影响。方法 采用薄膜分散法制备姜黄素胶束；通过胶束平均粒径、载药量、包封率等指标表征该胶束，同时测定姜黄素的溶解度；通过体外释放考察该胶束的释放特性；进一步通过大鼠实验评估胶束对姜黄素口服生物利用度的影响。结果 当VE-TPGS与SHS15加入质量比为3∶7时，胶束粒径为（35.79±1.23）nm，多分散性指数（PDI）为0.12±0.03；在该条件下，胶束的载药量和包封率分别为9.34%和90.03%，姜黄素的溶解度达到2.03 mg/mL；体外释放实验中，胶束组较姜黄素组有缓慢释放特性；大鼠口服生物利用度实验中，胶束组较姜黄素组的相对生物利用度提高到303.5%（P<0.01）。结论 本实验制备的胶束不仅有较好的缓释特性，还提高了姜黄素的溶解度和口服生物利用度。利用药物-胶束体系来改善难溶性药物的溶解度，具有较高的临床应用潜力。

Objective To prepare curcumin-micelles adopting vitamin E-TPGS (VE-TPGS) and Solutol HS15 (SHS15) as carriers, and study the effect on solubility and oral bioavailability of curcumin (Cur). Methods Cur was loaded into micelles between VE-TPGS and SHS15 by thin film dispersion method. Particle size, loading efficiency, entrapment efficiency, and in vitro release were carried on to estimate the influence of micelles on Cur; Moreover, oral bioavailability in rats was also evaluated. Results The particle size was (35.79±1.23) nm with polydispersity index (PDI) of 0.12±0.03 when the optimized micelles ratio was at 3:7 of VE-TPGS and SHS15, which increased the solubility of Cur to 2.03 mg/mL in water. The entrapment efficiency and drug loading were 90.03% and 9.34%, respectively. The in vitro release profile showed a sustained release property compared with that of Cur. In addition, the relative bioavailability of micelles (AUC_0~∞) compared with that of Cur (AUC_0~∞) was 303.5% (P<0.01). Conclusion The Cur-micelles combined use of VE-TPGS and SHS15 shows great potential clinical application.