[关键词]
[摘要]
目的 研究何首乌Polygonum multiflorum的化学成分。方法 采用大孔吸附树脂(DM-8型)、Sephadex LH-20、反相硅胶柱色谱和液相制备等多种色谱技术进行分离纯化,采用核磁共振等波谱技术进行结构鉴定。结果 从何首乌提取物55%乙醇洗脱部位中分离得到10个化合物,分别鉴定为thunberginol C 6-O-β-D-glucopyranoside(1)、对羟基苯甲醛(2)、反式-N-咖啡酰酪胺(3)、(Z)-2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(4)、(E)-2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(5)、白藜芦醇-3-O-β-D-(2"-O-没食子酰)-葡萄糖苷(6)、(E)-2,3,5,4'-四羟基二苯乙烯-2-O-β-D-(3"-没食子酰)-葡萄糖苷(7)、苜蓿素-7-O-β-D-葡萄糖苷(8)、torachrysone-8-O-β-D-glucoside(9)、大黄素-8-O-β-D-葡萄糖苷(10)。结论 化合物1为新化合物,命名为何首乌丁素。化合物3和8为首次从何首乌中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Polygonum multiflorum. Methods The constituents were isolated and purified by macroporous adsorbent resin (DM-8), gel chromatography, silica chromatography, and other modern separation methods, and the structures were identified by spectral analyses. Results Ten compounds were isolated and identified as thunberginol C 6-O-β-D-glucopyranoside (1), p-hydroxybenzaldehyde (2), trans-N-caffeoyltyramine (3), (Z)-2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (4), (E)-2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (5), pieceid-2"-O-gallate (6), (E)-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-(3"-galloyl)-glucoside (7), tricin-7-O-β-D-glucoside (8), torachrysone-8-O-β-D-glucoside (9), and emodin-8-O-β-D-glucoside (10). Conclusion Compound 1 is a new compound named as polygonimitin D. Compounds 3 and 8 are isolated from this plant for the first time.
[中图分类号]
[基金项目]