[关键词]
[摘要]
灯盏花制剂广泛地应用于脑卒中的治疗,以灯盏细辛提取物制备的药物中,咖啡酰奎宁酸类成分的数目、量都不容忽视。因此,对灯盏细辛中咖啡酰奎宁酸类成分的结构、含量、治疗缺血性脑卒中的临床报道以及对相关靶点的药理作用及其机制进行综述。灯盏细辛中已发现22个咖啡酰奎宁酸类化合物,占所有报道的灯盏细辛中化合物的29%;总多酚平均量为36.93%,灯盏细辛注射液中该类成分约占95%以上,高于灯盏乙素;临床研究证实灯盏细辛注射液能提高缺血性脑卒中急性期治疗的有效率,改善神经功能缺损,安全性好;药理研究显示咖啡酰奎宁酸类化合物具有抗氧化、抗自由基、抗凝血、抗炎和抗纤维化等作用,可以保护神经细胞、血管内皮细胞、神经胶质细胞、星形细胞等,抑制炎症因子白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)等,提升超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平,可以在缺血性脑卒中的不同治疗阶段发挥作用,是灯盏细辛中一类值得重视的化学成分。
[Key word]
[Abstract]
This paper summarized the chemical structures and amounts of caffeoylquinic acids in Erigeron breviscapus, as well as its prevention and cure effects on ischemic stroke in clinical and possible pharmacological mechanism. The results showed 22 caffeoylquinic acids reported from E. breviscapus, accounting for 29% of all compounds from this herb; The average content of total polyphenols was 36.93%, and more than 95% of components in Erigeron Breviscapus Injection are caffeoylquinic acids, higher than that of scutellarin. Several high quality clinical studies confirmed that Erigeron Breviscapus Injection enhanced treatment performance and improve the neurological score in the treatment after ischemic stroke and had good safety. In pharmacological research, caffeoylquinic acid compounds display anti-oxidant, anti-free radical, anticoagulation, and anti-fibrosis effects, which can protect neuro, vascular endothelial cells, glial cells, and astrocytes. They are also able to inhibit inflammatory, suppress cytokines IL-1, TNF-α, and enhance SOD & GSH-Px, which play a role in different treatment stages of ischemic stroke. So, caffeoylquinic acid is a kind of important chemical in E. breviscapus.
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[基金项目]
国家自然科学基金资助项目(81460631);昆明理工大学药物代谢平台建设项目(14078184)