目的 探索通过PET/CT显像将中药有效成分在体内的代谢过程变成可视的图像，并通过图像对其进行定量分析的可行性。方法 以延胡索的有效成分左旋千金藤啶碱（L-SPD）作为研究对象。使用正电子核素¹¹碳（¹¹C）标记L-SPD，在热室内化学合成¹¹C-L-SPD。SD大鼠戊巴比妥钠麻醉后固定于木板上，尾iv 37 MBq ¹¹C-L-SPD。分别于注射后5、15、30、45、60、90 min行PET/CT显像。使用工作站获得脑、心脏、肺脏、肝脏、肾脏、肠腔、膀胱的放射性容积分布比值（distribution volume ratios，DVR）。结果 PET/CT显像显示在5 min时¹¹C-L-SPD在肝脏、肾脏分布最多，心脏、肺、脑可见放射性分布。肝、肾是¹¹C-L-SPD的主要代谢及排泄器官，肝、肾、肠腔、膀胱在5 min DVR分别为（1.37±0.42）%、（1.10±0.19）%、（0.89±0.18）%、（0.97±0.11）%，90 min分别为（0.65±0.11）%、（0.54±0.05）%、（5.49±1.44）%、（9.86±1.88）%。结论 PET/CT显像可以直观、动态地观察L-SPD在活体内的分布及代谢特点，有望用于其他中药有效成分的活体显像研究。

Objective To exolpre the feasibility to transform the metabolic process of active constituents of Chinese herbal medicine in vivo into images by PET/CT and to make quantitative analysis. Methods The l-stepholidine was used as study object, and chemical synthesis of ¹¹C-L-SPD was performed in hot room. PET/CT scan was performed in different time, 5, 15, 30, 45, 60, and 90 min after injecting ¹¹C-L-SPD by vail in rats, and the information of brain, heart, lung, liver, kidney, intestine, and bladder was transferred to the Workststion. The distribution volume ratios(DVR) of the above tissues were obtained. Results ¹¹C-L-SPD was keeping in a relative higher level in liver and kidney at 5 min. metabolism through the liver, kidney was the main eccrisis organ. The distribution of ¹¹C-L-SPD in liver, kidney, intestine, and bladder was(1.37±0.42)%,(1.10±0.19)%,(0.89±0.18)%, and(0.97±0.111)% respectively at 5 min and was(0.65±0.11)%,(0.54±0.05)%,(5.49±1.44)%, and(9.86±1.88)% respectively at 90 min. Conclusion PET/CT imaging could observe the distribution and metabolism of ¹¹C-L-SPD dynamically and directly. It could be used in the research of other Chinese medicines.

上海市卫生与计划生育委员会中医药科研课题资助项目（2014JP004A）；上海市自然科学基金资助项目（15ZR1405400）；上海市卫生与计划生育委员会科研课题资助项目（2014440596）