目的 对白花败酱草Patrinia villosa的化学成分进行研究。方法 通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱方法分离纯化，根据理化性质和波谱数据鉴定化合物结构。结果 从白花败酱草干燥全草的70%乙醇提取物中分离得到了14个化合物，分别鉴定为异地芰普内酯（1）、citroside A（2）、grasshopper ketone（3）、（E）-4-hydroxy-3，3，5-trimethy1-4-（3-oxobut-1-en-1-yl）-cyclohexan-1-one（4）、bluemenol A（5）、pubinernoid A（6）、刺槐素（7）、葛根素（8）、5-（1'-hydroxyethyl）-methyl nicotinate（9）、2-[4-（3-hydroxypropyl）-2-methoxyphenoxy]-propane-1，3-diol（10）、1-O-（β-D-glucosyl）-2-[2-methoxy-4-（3-hydroxypropyl）-phenoxy]-propan-3-ol（11）、二氢芥子醇（12）、3，5-dimethoxyl-4-hydroxyl-phenylpropanol-9-O-β-D-glucopyranoside（13）、2-phenylethyl-α-L-arabinopyranosyl-（1"→6'）-β-D-glucopyranoside（14）。结论 所有化合物均为首次从败酱属植物中分离得到。

Objective To study the chemical constituents of Patrinia villosa. Methods Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20, and reversed-phase HPLC. Their structures were elucidated by physiochemical property and spectral analysis. Results Fourteen compounds were isolated and identified as isololiolide(1), citroside A(2), grasshopper kectone(3),(E)-4-Hydroxy-3, 3, 5-trimethy1-4-(3-oxobut-1-en-1-yl)-cyclohexan-1-one(4), bluemenol A(5), pubinernoid A(6), robinin(7), puerarin(8), 5-(1'-hydroxyethyl)-methyl nicotinate(9), 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propance-1, 3-diol(10), 1-O-(β-D-glucosyl)-2-[2-methoxy-4-(3-hydroxypropyl)-phenoxy]-propan-3-ol(11), dihydrosinapyl alcohol(12), 3, 5-dimethoxyl-4-hydroxyl-phenylpropanol-9-O-β-D-glucopyranoside(13), and 2-phenylethy-α-L-arabinopyranosyl-(1"→6')-β-D-glucopyranoside(14). Conclusion All compounds are isolated from the plants of Patrinia Juss. for the first time.

国家自然科学基金青年基金项目（81303211）；中国博士后科学基金项目（2013M540301）