[关键词]
[摘要]
目的 对八仙花Hydrangea macrophylla叶的化学成分进行研究。方法 采用硅胶柱色谱、ODS柱色谱和HPLC等方法进行分离纯化,并通过1H-NMR、13C-NMR、MS等波谱学技术确定化合物结构。结果 从八仙花叶提取物中分离得到11个环烯醚萜类化合物,分别鉴定为断马钱子苷乙基甲基缩醛(1)、断马钱子苷二甲基缩醛(2)、断氧化马钱子苷(3)、7-去氧马钱子酸(4)、马钱子酸(5)、8-表马钱子苷(6)、马钱子苷(7)、7-脱氢马钱子苷(8)、獐牙菜苷(9)、表断马钱子苷半缩醛内酯(10)、断马钱子苷半缩醛内酯(11)。结论 化合物1为新化合物,命名为八仙花叶苷。化合物3、8为八仙花属植物中首次分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents of the leaves of Hydrangea macrophylla. Methods The chemical constituents were separated and purified by various isolation methods(silica gel, ODS, and HPLC column chromatography), and their structures were determined by the analysis of spectral data(1H-NMR, 13C-NMR, and MS). Results Eleven compounds were obtained and elucidated as following:secologanin ethyl methyl acetal(1), secologanin dimethyl acetal(2), secoxyloganin(3), 7-deoxyloganic acid(4), loganic acid(5), 8-epi-loganin(6), loganin(7), 7-dehydrologanin(8), sweroside(9), epi-vogeloside(10), and vogeloside(11). Conclusion Compound 1 is a new compound, named as macrophyoside. Compounds 3 and 8 are isolated for the first time from the plants of Hydrangea Linn.
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[基金项目]
教育部博士点基金项目(20132327120002);黑龙江中医药大学“优秀创新人才”支持项目(2012RCD05);黑龙江中医药大学“杰出人才培养”基金项目(2012cj02)