目的 研究三七与丹参配伍对丹参中成分提取溶出的影响。方法 采用单因素实验和正交试验，以隐丹参酮、丹参酮II_A、迷迭香酸、丹酚酸B、固含物为考察指标，优选丹参醇提及水提最佳工艺条件。在最佳提取工艺条件下，将三七与丹参配伍，采用HPLC法检测丹参中成分提取溶出情况，并进行统计分析。结果 丹参醇提最佳工艺为浸泡0 h、10倍量75%乙醇提取2次，每次1.5 h。丹参水提最佳工艺为8倍量水提取3次，每次2 h。三七对丹参中主要成分丹参酮II_A和丹酚酸B的提取溶出无显著性影响，且三七对丹参中其他醇溶性成分和水溶性成分的提取溶出也无显著性影响。结论 三七对丹参中成分提取溶出无明显影响。

Objective To study the effect of compatibility of Notoginseng Radix et Rhizoma (NRR) with Salviae Miltiorrhizae Radix et Rhizoma (SMRR) on the extraction of SMRR compositions. Methods The optimum technology conditions of aqueous and alcohol extraction of SMRR were elected by single factor and orthogonal experiments with the contents of cryptotanshinone, tanshinone II_A, rosmarinic acid, salvianolic acid B and solid content as the investigation index. Under the optimum extraction conditions, the dissolution compositions of SMRR were detected as it was compatible with NRR by HPLC, and data were analyzed. Results The optimum technology conditions of the SMRR's alcohol extraction were 10 times amount of 75% alcohol refluxing and extracting twice, each time 1.5 h, and soaking for 0 h. The optimum technology conditions of the SMRR's aqueous extraction were 8 times amount of water refluxing and extracting 3 times, each time 2 h. NRR had no significant effect on the extraction of tanshinone II_A and salvianolic acid B as principal components from SMRR, and the effect of NRR on other alcohol-soluble components and water-soluble extraction of SMRR also had no significant improvement. Conclusion NRR had no obvious effect on the dissolution of SMRR compositions.

四川千人计划支持项目（2013332）；四川省中医药管理局中医药科学技术研究专项（2014F004）；四川省科技厅丹参整合式全产业链综合开发研究（2014SZ0136）