[关键词]
[摘要]
目的 研究一口钟(蓝桉Eucalyptus globulus果实)中的化学成分。方法 综合运用正相硅胶柱色谱、凝胶渗透柱色谱、半制备HPLC色谱等方法分离、纯化一口钟中的化学成分,采用NMR和质谱等波谱学方法鉴定化合物结构。结果 从一口钟中分离得到12个化合物,分别鉴定为1,10-dioxotayloriane(1)、litseagermacrane(2)、蓝桉醇(3)、表蓝桉醇(4)、绿花白千层醇(5)、齐墩果酸(6)、白桦脂酸(7)、熊果酸(8)、11α-甲氧基熊果酸(9)、1-(2,6-dihydroxy-4-methoxy-3,5-dimethylphenyl)-2-methylbutan-1-one(10)、鞣花酸(11)、3-甲氧基鞣花酸-4'-O-α-L-吡喃鼠李糖苷(12)。结论 化合物1和2为首次从该属植物中分离得到,化合物9和10为首次从该种植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the fruits of Eucalyptus globulus. Methods The chemical constituents were separated by column chromatography, such as silica gel, sephadex LH-20, and semi-preparative HPLC. On the basis of spectral data analysis, their structures were elucidated. Results Twelve compounds were isolated and purified which structures were elucidated as 1,10-dioxotayloriane (1), litseagermacrane (2), (-)-globulol (3), (-)-epiglobulol (4), viridiflorol (5), oleanolic acid (6), betulinic acid (7), ursolic acid (8), robustanic acid (9), 1-(2,6-dihydroxy-4-methoxy-3,5-dimethylphenyl)-2-methylbutan-1-one (10), ellagic acid (11), and 3-O-methylellagic acid-4'-O-α-L-rhamnopyranoside (12). Conclusion Compounds 1 and 2 are isolated from the Eucalyptus L. Herit for the first time, compounds 9 and 10 are isolated from this plant for the first time.
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[基金项目]
天津市自然科学基金重点项目(16JCZDJC32600);中国博士后基金资助项目(2016M591399);天然药物活性物质与功能国家重点实验室开放课题(GTZK201601)