目的 对桂枝茯苓胶囊内容物正丁醇和醋酸乙酯萃取部位进行化学成分研究。方法 采用多种色谱方法对桂枝茯苓胶囊内容物的正丁醇和醋酸乙酯萃取部位进行分离纯化，根据理化性质和波谱数据鉴定其结构。结果 从醋酸乙酯和正丁醇层分离得到10个化合物，分别鉴定为对羟基苯甲酸（1）、反式邻甲氧基桂皮酸（2）、反式桂皮酸（3）、对香豆酸（4）、2，5-dihydroxy-4-methylacetophenone（5）、没食子酸乙酯（6）；从正丁醇层分离得到4个化合物，分别为香草酸（7）、原儿茶酸（8）、affinoside（9）、benzyl-β-D-glucopyranosyl-（1→6）-β-D-glucopyranoside（10）。结论 化合物1~10均为首次从该复方中分离得到。

Objective To study the chemical constituents from the ethyl acetate and n-butanol extract of Guizhi Fuling Capsule.Methods The chemical constituents were isolated and purified by multiple chromatographic methods. Their structures were identified on the basis of the spectral data and physicochemical properties.Results Ten compounds were identified as 4-hydroxybenzoic acid (1), trans- O-methoxy cinnamic acid (2), trans-cinnamic acid (3), 4-hydroxycinnamic acid (4), 2,5-dihydroxy-4-methylacetophenone (5), ethyl gallate (6), vanillic acid (7), protocatechuic acid (8), affinoside (9), and benzyl-β- D-glucopyranosyl-(1→6)-β- D-glucopyranoside (10).Conclusion Compounds 1—10 are isolated from this plant for the first time.

科技部重大新药创制：现代中药创新集群与数字制药技术平台（2013ZX09402203）