目的 对山东产忍冬藤Lonicerae Japonicae Caulis进行化学成分研究。方法 通过反复硅胶、MCI-gel树脂、Sephadex LH-20等多种柱色谱技术进行化学成分分离纯化，依据化合物理化性质和波谱学数据鉴定其结构。结果 从山东产忍冬藤中分离并鉴定了4个化合物，分别为11，14，15-三羟基-12-烯-十八碳酸甲酯（1）、金莲木黄酮（2）、β-胡萝卜苷（3）、马钱素（4）。结论 化合物1为一个新化合物，命名为忍冬酸酯，化合物2为首次从忍冬藤中分离得到。

Objective To study the chemical constituents of Lonicerae Japonicae Caulis produced in Shandong Province.Methods Compounds were isolated and purified by repeated column chromatographies including silica gel, MCI-gel resin, Sephadex LH-20, and so on. Their structures were elucidated by spectral data, including extensive 1D and 2D NMR techniques.Results Four compounds were obtained and identified as 11,14,15-trihydroxy-12-octadecenoic acid methyl ester (1), ochnaflavone (2), β-daucosterol (3), and loganin (4).Conclusion Compound 1 is a new organic acid named as loniceric acid ester, and compound 2 is isolated from Lonicerae Japonicae Caulis for the first time.

国家“十二五”科技支撑计划课题资助项目（2011BAI06B01）；山东省医学科学院科技计划项目（2015-23）