[关键词]
[摘要]
目的 研究壮药龙脷叶Sauropus rostratus的化学成分。方法 通过硅胶、聚酰胺、MCI、凝胶等柱色谱及重结晶方法进行分离和纯化,根据理化性质和波谱数据对化合物结构进行鉴定。结果 从龙脷叶75%乙醇提取物中分离得到19个化合物,分别鉴定为正三十烷醇(1)、2,4-二叔丁基苯酚(2)、β-谷甾醇(3)、胡萝卜苷(4)、3,6-anhydro-2-deoxy-D-arabino-hexono-l,4-lactone(5)、烟酰胺(6)、东莨菪亭(7)、3β-hydroxy-26α,27β-arbor-13(18)-ene-24-carboxylic acid(8)、2R*,3R*,5S*-trihydroxy-6R*-nonadecyltetrahydropyran-4-one(9)、大黄素(10)、原儿茶酸(11)、2,3-dideoxy-D-erythro-hex-2-enono-1,4-lactone(12)、咖啡酸(13)、3-乙酰氧基咖啡酸(14)、槲皮素(15)、D-半乳糖(16)、甘露醇(17)、橙黄胡椒酰胺(18)、山柰酚(19)。结论 化合物8为新化合物,命名为龙脷叶酸;化合物2、5~14、16~18均为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Zhuang medicine Sauropus rostratu. Methods The compounds were isolated and purified by silica gel, polyamide, MCI, and Sephadex LH-20 chromatography. The structures of the compounds were identified on the basis of chemical and spectral methods. Results Nineteen compounds were isolated from 75% ethanol extrct of S. rostratu and identified as n-triacontanol (1), 2,4-di-tert-butylphenol (2), β-sitosterol (3), daucosterol (4), 3,6-anhydro-2-deoxy-D-arabino-hexono-1,4-lactone (5), niacinamide (6), scopoletin (7), 3β-hydroxy-26α,27β-arbor-13(18)-ene-24-carboxylic acid (8), 2R*,3R*,5S*-trihydroxy-6R*-nonadecyltetrahydropyran-4-one (9), emodin (10), protocatechuic acid (11), 2,3-dideoxy-D-erythro-hex-2-enono-1,4-lactone (12), caffeic acid (13), 3-acetrlc-affeic acid (14), quercetin (15), D-galactose (16), mannitol (17), aurantiamide acetate (18), and kaempferol (19). Conclusion Compound 8 is a new compound named sauropurostratic acid, and compounds 2,5-14,and 16-18 are isolated from this plant for the first time.
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[基金项目]
国家科技支撑计划项目课题(2013BAI11B06);广西科技厅重大专项计划课题(桂科重1355001-4-1);广西高等学校优秀中青年骨干教师培养工程(桂教人[2013]16号)