目的 对傣药翅荚决明Cassia alata细枝的化学成分进行研究，以期发现新的活性化合物。方法 运用硅胶、凝胶、MCI-GEL树脂及RP-HPLC等多种色谱技术进行分离纯化，根据理化性质和波谱数据鉴定化合物的结构，并用MTT法测定了化合物对NB4、A-549、SHSY5Y、PC-3和MCF-7 5种人源肿瘤细胞株的细胞毒活性。结果 从翅荚决明细枝中分离鉴定了4个2-芳基苯并呋喃类化合物，分别鉴定为7-甲氧基-2-（4-甲氧基苯基）-3,5-二甲基苯并呋喃（1）、桑辛素N（2）、2-（2’-甲氧基-4’-羟基苯基）-3-甲基-6-羟基苯并呋喃（3）、桑辛素P（4）。结论 化合物1为新化合物，命名为翅荚决明素A，该化合物对所测试的人源肿瘤细胞具有一定的细胞毒活性。

Objective For the purpose of finding new bioactive agents from ethnic medicines, the chemical study on Dai Medicine Cassia alata was carried out. Methods The chemical constituents from the twigs of C. alata were isolated by column chromatographic methods of silica gel, MCI-Gel resin, Sephadex LH-20, and HPLC. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The cytotoxicity of this compound for NB-4, A-549, SHSY5Y, PC-3, and MCF-7 cells line was also evaluated by using the MTT method. Results Four 2-arylbenzofuran compounds were isolated from this plant and identified as 7-methoxy-2-(4-methoxyphenyl)-3,5-dimethylbenzofuran (1), moracin N (2), 2-(2'-methoxy-4'-hydroxy-aryl)-3-methy-6-hydroxybenzofuran (3), and moracin P (4). Conclusion Compound 1 is a new compound named as 7-methoxy-2-(4-methoxyphenyl)-3,5-dimethylbenzofuran. Compound 1 also displays the high cytotoxicity to tested cancer cell-line.

国家自然科学基金资助项目（21362044，21032085）；云南省高校科技创新团队资助项目（IRTSTYN2014-11）