[关键词]
[摘要]
中药质量控制一直是中药现代化研究的难点和重点,而药效组分群的辨识则是支撑中药质量控制的前提和基石,是中药的创新与发展探索的重要方向。药效组分群的研究方法虽众多,但仍处于探索阶段尚需在理论上加以提高,加强其系统性。从中药药效组分群发展历程出发,系统总结和分析现行药效组分群的筛选思路、组分配伍、质控模式等内容,探讨从复杂成分群中寻找“药效组分群”的方法,并构建配伍关系的研究思路,以期又快又准地锁定中药药效关键组分,实现中药质量标准“关联药效,量而又准,可控可评”的愿景,为后续质量评价体系的构建提供借鉴。
[Key word]
[Abstract]
The quality control of Chinese materia medica (CMM) has been the focus of the modernization of CMM, while the screening of efficient constituents in CMM provides the prerequisite and foundation for quality control. Numerous methods had been used for studying the efficient constituents in CMM, but still in the exploratory stage. It still needs to be developed in theory and systemic integration. This article reviewed the development of CMM, analyzed the screening ideas, component compatibility, and quality control mode of the existing efficient components in CMM, for seeking the efficient components in CMM from the complex component groups and building the research ideas of compatibility relations. Its main aim was to provide the reference for the construction of the follow-up quality evaluation system to recognize the key efficient components of CMM precisely and quickly, and to meet with the requirements that the quality control standards for CMM would be effectiveness-related, quantitative and accurate, controllable and assessable.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81560649);江西省卫生计生委中医药科技项目(2015B041);江西省教育厅科技项目(GJJ14623)